Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

The structure of BG505 gp140 SOSIP, a soluble mimic of the native HIV-1 envelope glycoprotein (Env), marks the beginning of new era in Env structure-based immunogen design. Displaying a well-ordered quaternary structure, these subtype A-derived trimers display an excellent antigenic profile, discrim...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Guenaga, Javier, de Val, Natalia, Tran, Karen, Feng, Yu, Satchwell, Karen, Ward, Andrew B., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287557/
https://ncbi.nlm.nih.gov/pubmed/25569572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004570
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