Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. Here, we analyzed multiple new designs to explore a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Yang, Lifei, Sharma, Shailendra Kumar, Cottrell, Christopher, Guenaga, Javier, Tran, Karen, Wilson, Richard, Behrens, Anna-Janina, Crispin, Max, de Val, Natalia, Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056610/
https://ncbi.nlm.nih.gov/pubmed/30065725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01631
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