Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

Native-like trimers of the SOSIP design are being developed as immunogens in human immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers display the epitopes for multiple broadly neutralizing antibodies (bNAbs) but can also expose binding sites for some types of nonneutra...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ringe, Rajesh P., Ozorowski, Gabriel, Rantalainen, Kimmo, Struwe, Weston B., Matthews, Katie, Torres, Jonathan L., Yasmeen, Anila, Cottrell, Christopher A., Ketas, Thomas J., LaBranche, Celia C., Montefiori, David C., Cupo, Albert, Crispin, Max, Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W., Klasse, P. J., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512241/
https://ncbi.nlm.nih.gov/pubmed/28539451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00677-17
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