Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing antibody (NAb) induction. The attached trimers, ∼20 per particle, retained native-like antigenicity, judged by reactivity with...

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發表在:J Virol
Main Authors: Ringe, Rajesh P., Cruz Portillo, Victor M., Dosenovic, Pia, Ketas, Thomas J., Ozorowski, Gabriel, Nogal, Bartek, Perez, Lautaro, LaBranche, Celia C., Lim, Jillian, Francomano, Erik, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., Montefiori, David C., Nussenzweig, Michel C., Klasse, P. J., Cupo, Albert, Moore, John P.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158715/
https://ncbi.nlm.nih.gov/pubmed/31852794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01883-19
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