Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing antibody (NAb) induction. The attached trimers, ∼20 per particle, retained native-like antigenicity, judged by reactivity with...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Ringe, Rajesh P., Cruz Portillo, Victor M., Dosenovic, Pia, Ketas, Thomas J., Ozorowski, Gabriel, Nogal, Bartek, Perez, Lautaro, LaBranche, Celia C., Lim, Jillian, Francomano, Erik, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., Montefiori, David C., Nussenzweig, Michel C., Klasse, P. J., Cupo, Albert, Moore, John P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Vaccines and Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158715/
https://ncbi.nlm.nih.gov/pubmed/31852794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01883-19
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