Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing antibody (NAb) induction. The attached trimers, ∼20 per particle, retained native-like antigenicity, judged by reactivity with...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ringe, Rajesh P., Cruz Portillo, Victor M., Dosenovic, Pia, Ketas, Thomas J., Ozorowski, Gabriel, Nogal, Bartek, Perez, Lautaro, LaBranche, Celia C., Lim, Jillian, Francomano, Erik, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., Montefiori, David C., Nussenzweig, Michel C., Klasse, P. J., Cupo, Albert, Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158715/
https://ncbi.nlm.nih.gov/pubmed/31852794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01883-19
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