Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

The native-like, soluble SOSIP.664 trimer based on the BG505 clade A env gene of HIV-1 is immunogenic in various animal species, of which the most studied are rabbits and rhesus macaques. The trimer induces autologous neutralizing antibodies (NAbs) consistently but at a wide range of titers and with...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Klasse, P. J., Ketas, Thomas J., Cottrell, Christopher A., Ozorowski, Gabriel, Debnath, Gargi, Camara, Diawoye, Francomano, Erik, Pugach, Pavel, Ringe, Rajesh P., LaBranche, Celia C., van Gils, Marit J., Bricault, Christine A., Barouch, Dan H., Crotty, Shane, Silvestri, Guido, Kasturi, Sudhir, Pulendran, Bali, Wilson, Ian A., Montefiori, David C., Sanders, Rogier W., Ward, Andrew B., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841823/
https://ncbi.nlm.nih.gov/pubmed/29474444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006913
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