Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

The induction of broadly neutralizing antibodies (bNAbs) is a major goal in the development of an effective vaccine against HIV-1. A soluble, trimeric, germline (gI) bNAb-targeting variant of the HIV-1 envelope glycoprotein (termed BG505 SOSIP.v4.1-GT1.1 gp140, abbreviated to GT1.1) has recently bee...

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Détails bibliographiques
Publié dans:J Pharm Sci
Auteurs principaux: Whitaker, Neal, Hickey, John M., Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Cupo, Albert, Lee, Wen-Hsin, Ozorowski, Gabriel, Medina-Ramírez, Max, Ward, Andrew B., Sanders, Rogier W., Moore, John P., Joshi, Sangeeta B., Volkin, David B., Dey, Antu K.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595180/
https://ncbi.nlm.nih.gov/pubmed/30776383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.01.033
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