A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One approach to the problem is to create trimeric mimics of the native envelope glycoprotein (Env) spike that expose as many...

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Main Authors: Sanders, Rogier W., Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Yasmeen, Anila, de Val, Natalia, Kim, Helen J., Blattner, Claudia, de la Peña, Alba Torrents, Korzun, Jacob, Golabek, Michael, de los Reyes, Kevin, Ketas, Thomas J., van Gils, Marit J., King, C. Richter, Wilson, Ian A., Ward, Andrew B., Klasse, P. J., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777863/
https://ncbi.nlm.nih.gov/pubmed/24068931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003618
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