Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

A key challenge in the quest toward an HIV-1 vaccine is design of immunogens that can generate a broadly neutralizing antibody (bnAb) response against the enormous sequence diversity of the HIV-1 envelope glycoprotein (Env). We previously demonstrated that a recombinant, soluble, fully cleaved SOSIP...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Julien, Jean-Philippe, Lee, Jeong Hyun, Ozorowski, Gabriel, Hua, Yuanzi, Torrents de la Peña, Alba, de Taeye, Steven W., Nieusma, Travis, Cupo, Albert, Yasmeen, Anila, Golabek, Michael, Pugach, Pavel, Klasse, P. J., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586835/
https://ncbi.nlm.nih.gov/pubmed/26372963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507793112
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