SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

Soluble recombinant native-like (NL) envelope glycoprotein (Env) trimers of various human immunodeficiency virus type 1 (HIV-1) genotypes are being developed as vaccine candidates aimed at the induction of broadly neutralizing antibodies (bNAbs). The prototypic design, designated BG505 SOSIP.664, in...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Ringe, Rajesh P., Colin, Philippe, Torres, Jonathan L., Yasmeen, Anila, Lee, Wen-Hsin, Cupo, Albert, Ward, Andrew B., Klasse, P. J., Moore, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912111/
https://ncbi.nlm.nih.gov/pubmed/31619555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01521-19
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