Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

A key challenge in the quest toward an HIV-1 vaccine is design of immunogens that can generate a broadly neutralizing antibody (bnAb) response against the enormous sequence diversity of the HIV-1 envelope glycoprotein (Env). We previously demonstrated that a recombinant, soluble, fully cleaved SOSIP...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Julien, Jean-Philippe, Lee, Jeong Hyun, Ozorowski, Gabriel, Hua, Yuanzi, Torrents de la Peña, Alba, de Taeye, Steven W., Nieusma, Travis, Cupo, Albert, Yasmeen, Anila, Golabek, Michael, Pugach, Pavel, Klasse, P. J., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586835/
https://ncbi.nlm.nih.gov/pubmed/26372963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507793112
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