Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

A key challenge in the quest toward an HIV-1 vaccine is design of immunogens that can generate a broadly neutralizing antibody (bnAb) response against the enormous sequence diversity of the HIV-1 envelope glycoprotein (Env). We previously demonstrated that a recombinant, soluble, fully cleaved SOSIP...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Julien, Jean-Philippe, Lee, Jeong Hyun, Ozorowski, Gabriel, Hua, Yuanzi, Torrents de la Peña, Alba, de Taeye, Steven W., Nieusma, Travis, Cupo, Albert, Yasmeen, Anila, Golabek, Michael, Pugach, Pavel, Klasse, P. J., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586835/
https://ncbi.nlm.nih.gov/pubmed/26372963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507793112
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