High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

par Chaudhuri, Rajoshi, Cheng, Yuan, Middaugh, C. Russell, Volkin, David B.
Publié 2013

Application of radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques

par Kalonia, Cavan, Kumru, Ozan S., Kim, Jae Hyun, Middaugh, C. Russell, Volkin, David B.
Publié 2013

Comparative evaluation of the chemical stability of four well-defined IgG1 Fc glycoforms

par Mozziconacci, Olivier, Okbazghi, Solomon, More, Apurva S., Volkin, David B., Tolbert, Thomas, Schöneich, Christian
Publié dans J Pharm Sci (2016)

Improved data visualization techniques for analyzing macromolecule structural changes

par Kim, Jae Hyun, Iyer, Vidyashankara, Joshi, Sangeeta B, Volkin, David B, Middaugh, C Russell
Publié 2012

The Science is There: Key Considerations for Stabilizing Viral Vector-Based Covid-19 Vaccines

par Crommelin, Daan J.A., Volkin, David B., Hoogendoorn, Karin H., Lubiniecki, Anthony S., Jiskoot, Wim
Publié dans J Pharm Sci (2021)

Addressing the Cold Reality of mRNA Vaccine Stability

par Crommelin, Daan J.A., Anchordoquy, Thomas J., Volkin, David B., Jiskoot, Wim, Mastrobattista, Enrico
Publié dans J Pharm Sci (2021)

Multidimensional Methods for the Formulation of Biopharmaceuticals and Vaccines

par Maddux, Nathaniel R., Joshi, Sangeeta B., Volkin, David B., Ralston, John P., Middaugh, C. Russell
Publié 2011

Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles

par Alsenaidy, Mohammad A., Jain, Nishant K., Kim, Jae H., Middaugh, C. Russell, Volkin, David B.
Publié 2014

An Improved Methodology for Multidimensional High-Throughput Preformulation Characterization of Protein Conformational Stability

par Maddux, Nathaniel R., Rosen, Ilan T., Hu, Lei, Olsen, Christopher M., Volkin, David B., Middaugh, C. Russell
Publié 2012

Two Decades of Publishing Excellence in Pharmaceutical Biotechnology

par VOLKIN, DAVID B., HERSHENSON, SUSAN, HO, RODNEY J. Y., UCHIYAMA, SUSUMU, WINTER, GERHARD, CARPENTER, JOHN F.
Publié dans J Pharm Sci (2014)

Crystallization of a nonreplicating rotavirus vaccine candidate

par Hong, Moo Sun, Kaur, Kawaljit, Sawant, Nishant, Joshi, Sangeeta B., Volkin, David B., Braatz, Richard D.
Publié dans Biotechnol Bioeng (2021)

Structural Characterization of IgG1 mAb Aggregates and Particles Generated under Various Stress Conditions

par Telikepalli, Srivalli N., Kumru, Ozan S., Kalonia, Cavan, Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.
Publié 2014

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

par Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Volkin, David B, Weis, David D
Publié dans MAbs (2014)

Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies

par Thakkar, Santosh V, Sahni, Neha, Joshi, Sangeeta B, Kerwin, Bruce A, He, Feng, Volkin, David B, Middaugh, C Russell
Publié 2013

Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array

par Wan, Ying, Hickey, John M., Bird, Christopher, Witham, Katey, Fahey, Paul, Forster, Angus, Joshi, Sangeeta B., Volkin, David B.
Publié dans J Pharm Sci (2018)

Comparison of the Structural Stability and Dynamic Properties of Recombinant Anthrax Protective Antigen and its 2-Fluorohistidine Labeled Analogue

par Hu, Lei, Joshi, Sangeeta B., Andra, Kiran K., Thakkar, Santosh V., Volkin, David B., Bann, James G., Middaugh, C. Russell
Publié 2012

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

par Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publié dans Vaccine (2017)

Effect of Two Emulsion-Based Adjuvants on the Structure and Thermal Stability of S. aureus Alpha-toxin

par Wei, Yangjie, Xiong, Jian, Larson, Nicholas R., Iyer, Vidyashankara, Sanyal, Gautam, Joshi, Sangeeta B., Volkin, David B., Middaugh, C. Russell
Publié dans J Pharm Sci (2018)

Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine

par Agarwal, Sanjeev, Sahni, Neha, Hickey, John M., Robertson, George A., Sitrin, Robert, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publié dans J Pharm Sci (2020)

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

par Lee, Shwu-Maan, Hickey, John M., Miura, Kazutoyo, Joshi, Sangeeta B., Volkin, David B., King, C. Richter, Plieskatt, Jordan L.
Publié dans Sci Rep (2020)