Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein’s structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628956/
https://ncbi.nlm.nih.gov/pubmed/28551040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.03.101
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