Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein’s structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine
Main Authors: Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Format: Artigo
Language:Inglês
Published: Elsevier Science 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628956/
https://ncbi.nlm.nih.gov/pubmed/28551040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.03.101
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items