Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies

Aggregation of monoclonal antibodies is often a multi-step process involving structural alterations in monomeric proteins and subsequent formation of soluble or insoluble oligomers. The role of local conformational stability and dynamics of native and/or partially altered structures in determining t...

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Detaylı Bibliyografya
Asıl Yazarlar: Thakkar, Santosh V, Sahni, Neha, Joshi, Sangeeta B, Kerwin, Bruce A, He, Feng, Volkin, David B, Middaugh, C Russell
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2013
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795488/
https://ncbi.nlm.nih.gov/pubmed/23893936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2316
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