High-Throughput Biophysical Analysis and Data Visualization of Conformational Stability of an IgG1 Monoclonal Antibody (mAb) After Deglycosylation

The structural integrity and conformational stability of an IgG1 monoclonal antibody (mAb), after partial and complete enzymatic removal of the N-linked Fc glycan, was compared to the untreated mAb over a wide range of temperature (10° to 90°C) and solution pH (3 to 8) using circular dichroism, fluo...

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Bibliografski detalji
Glavni autori: Alsenaidy, Mohammad A., Kim, Jae Hyun, Majumdar, Ranajoy, Weis, David D., Joshi, Sangeeta B., Tolbert, Thomas J., Middaugh, C. Russell, Volkin, David B.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832129/
https://ncbi.nlm.nih.gov/pubmed/24114789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23730
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