Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

There is a need for new analytical approaches to better characterize the nature of the concentration-dependent, reversible self-association (RSA) of monoclonal antibodies (mAbs) directly, and with high resolution, when these proteins are formulated as highly concentrated solutions. In the work repor...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Arora, Jayant, Hickey, John M, Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Weis, David D, Volkin, David B
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622866/
https://ncbi.nlm.nih.gov/pubmed/25875351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1029217
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