Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

This study compares the local conformational dynamics and physical stability of an IgG1 mAb (mAb-A) with its corresponding YTE (M255Y/S257T/T259E) mutant (mAb-E), which was engineered for extended half-life in vivo. Structural dynamics was measured using hydrogen/deuterium (H/D) exchange mass spectr...

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Pubblicato in:MAbs
Autori principali: Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Volkin, David B, Weis, David D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623389/
https://ncbi.nlm.nih.gov/pubmed/25524268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985494
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