Structural Characterization of IgG1 mAb Aggregates and Particles Generated under Various Stress Conditions

IgG1 mAb solutions were prepared with and without sodium chloride and subjected to different environmental stresses. Formation of aggregates and particles of varying size was monitored by a combination of size exclusion chromatography (SEC), Nanosight Tracking Analysis (NTA), Micro-flow Imaging (MFI...

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Main Authors: Telikepalli, Srivalli N., Kumru, Ozan S., Kalonia, Cavan, Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040128/
https://ncbi.nlm.nih.gov/pubmed/24452866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23839
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