High-Throughput Biophysical Analysis and Data Visualization of Conformational Stability of an IgG1 Monoclonal Antibody (mAb) After Deglycosylation

The structural integrity and conformational stability of an IgG1 monoclonal antibody (mAb), after partial and complete enzymatic removal of the N-linked Fc glycan, was compared to the untreated mAb over a wide range of temperature (10° to 90°C) and solution pH (3 to 8) using circular dichroism, fluo...

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Päätekijät: Alsenaidy, Mohammad A., Kim, Jae Hyun, Majumdar, Ranajoy, Weis, David D., Joshi, Sangeeta B., Tolbert, Thomas J., Middaugh, C. Russell, Volkin, David B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832129/
https://ncbi.nlm.nih.gov/pubmed/24114789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23730
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