Laddar...

High-Throughput Biophysical Analysis and Data Visualization of Conformational Stability of an IgG1 Monoclonal Antibody (mAb) After Deglycosylation

The structural integrity and conformational stability of an IgG1 monoclonal antibody (mAb), after partial and complete enzymatic removal of the N-linked Fc glycan, was compared to the untreated mAb over a wide range of temperature (10° to 90°C) and solution pH (3 to 8) using circular dichroism, fluo...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Alsenaidy, Mohammad A., Kim, Jae Hyun, Majumdar, Ranajoy, Weis, David D., Joshi, Sangeeta B., Tolbert, Thomas J., Middaugh, C. Russell, Volkin, David B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832129/
https://ncbi.nlm.nih.gov/pubmed/24114789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23730
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!