Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

Similar to other type I fusion machines, the HIV-1 envelope glycoprotein (Env) requires proteolytic activation; specifically, cleavage of a gp160 precursor into gp120 and gp41 subunits creates an N-terminal gp41 fusion peptide and permits folding from an immature uncleaved state to a mature closed s...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Georgiev, Ivelin S., Joyce, M. Gordon, Yang, Yongping, Sastry, Mallika, Zhang, Baoshan, Baxa, Ulrich, Chen, Rita E., Druz, Aliaksandr, Lees, Christopher R., Narpala, Sandeep, Schön, Arne, Van Galen, Joseph, Chuang, Gwo-Yu, Gorman, Jason, Harned, Adam, Pancera, Marie, Stewart-Jones, Guillaume B. E., Cheng, Cheng, Freire, Ernesto, McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442528/
https://ncbi.nlm.nih.gov/pubmed/25740988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03451-14
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