Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

Native-like trimers of the SOSIP design are being developed as immunogens in human immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers display the epitopes for multiple broadly neutralizing antibodies (bNAbs) but can also expose binding sites for some types of nonneutra...

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Publicado en:J Virol
Autores principales: Ringe, Rajesh P., Ozorowski, Gabriel, Rantalainen, Kimmo, Struwe, Weston B., Matthews, Katie, Torres, Jonathan L., Yasmeen, Anila, Cottrell, Christopher A., Ketas, Thomas J., LaBranche, Celia C., Montefiori, David C., Cupo, Albert, Crispin, Max, Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W., Klasse, P. J., Moore, John P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512241/
https://ncbi.nlm.nih.gov/pubmed/28539451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00677-17
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