Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally rede...

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Pubblicato in:Nat Commun
Autori principali: Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931249/
https://ncbi.nlm.nih.gov/pubmed/27349805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12040
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