Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally rede...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931249/
https://ncbi.nlm.nih.gov/pubmed/27349805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12040
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