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Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally rede...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931249/ https://ncbi.nlm.nih.gov/pubmed/27349805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12040 |
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