Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure

The HIV-1 envelope spike [trimeric (gp160)(3), cleaved to (gp120/gp41)(3)] is the mediator of viral entry and the principal target of humoral immune response to the virus. Production of a recombinant preparation that represents the functional spike poses a challenge for vaccine development, because...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kovacs, James M., Noeldeke, Erik, Ha, Heather Jiwon, Peng, Hanqin, Rits-Volloch, Sophia, Harrison, Stephen C., Chen, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284565/
https://ncbi.nlm.nih.gov/pubmed/25512514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422269112
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