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Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure
The HIV-1 envelope spike [trimeric (gp160)(3), cleaved to (gp120/gp41)(3)] is the mediator of viral entry and the principal target of humoral immune response to the virus. Production of a recombinant preparation that represents the functional spike poses a challenge for vaccine development, because...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4284565/ https://ncbi.nlm.nih.gov/pubmed/25512514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422269112 |
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