Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120). The design of soluble versions of trimeric Env that display structural and function...

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Detalhes bibliográficos
Main Authors: Harris, Audray, Borgnia, Mario J., Shi, Dan, Bartesaghi, Alberto, He, Haifeng, Pejchal, Robert, Kang, Yun (Kenneth), Depetris, Rafael, Marozsan, Andre J., Sanders, Rogier W., Klasse, Per Johan, Milne, Jacqueline L. S., Wilson, Ian A., Olson, William C., Moore, John P., Subramaniam, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136299/
https://ncbi.nlm.nih.gov/pubmed/21709254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101414108
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