Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120). The design of soluble versions of trimeric Env that display structural and function...

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Main Authors: Harris, Audray, Borgnia, Mario J., Shi, Dan, Bartesaghi, Alberto, He, Haifeng, Pejchal, Robert, Kang, Yun (Kenneth), Depetris, Rafael, Marozsan, Andre J., Sanders, Rogier W., Klasse, Per Johan, Milne, Jacqueline L. S., Wilson, Ian A., Olson, William C., Moore, John P., Subramaniam, Sriram
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136299/
https://ncbi.nlm.nih.gov/pubmed/21709254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101414108
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