HIV-1 Envelope Glycoprotein Trimers Display Open Quaternary Conformation When Bound to the gp41 Membrane-Proximal External-Region-Directed Broadly Neutralizing Antibody Z13e1

We describe cryo-electron microscopic studies of the interaction between the ectodomain of the trimeric HIV-1 envelope glycoprotein (Env) and Z13e1, a broadly neutralizing antibody that targets the membrane-proximal external region (MPER) of the gp41 subunit. We show that Z13e1-bound Env displays an...

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Bibliografiske detaljer
Main Authors: Harris, Audray K., Bartesaghi, Alberto, Milne, Jacqueline L. S., Subramaniam, Sriram
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676106/
https://ncbi.nlm.nih.gov/pubmed/23596305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03284-12
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