Structure of an HIV-1–neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer

The membrane proximal external region (MPER) of HIV-1 glycoprotein (gp) 41 is involved in viral–host cell membrane fusion. It contains short amino acid sequences that are binding sites for the HIV-1 broadly neutralizing antibodies 2F5, 4E10, and 10E8, making these binding sites important targets for...

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Detalhes bibliográficos
Main Authors: Reardon, Patrick N., Sage, Harvey, Dennison, S. Moses, Martin, Jeffrey W., Donald, Bruce R., Alam, S. Munir, Haynes, Barton F., Spicer, Leonard D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910588/
https://ncbi.nlm.nih.gov/pubmed/24474763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309842111
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