Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution

The conserved membrane-proximal external region (MPER) of HIV-1 envelope is a target for the rare broadly neutralizing 2F5, Z13, and 4E10 monoclonal antibodies (mAbs). One strategy to elicit such antibodies is to design an immunogen with increased exposure of the 2F5 and 4E10 mAb epitopes. In this s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shen, Xiaoying, Dennison, S. Moses, Liu, Pinghuang, Gao, Feng, Jaeger, Frederick, Montefiori, David C., Verkoczy, Laurent, Haynes, Barton F., Alam, S. Munir, Tomaras, Georgia D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851912/
https://ncbi.nlm.nih.gov/pubmed/20231447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912381107
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados