Differential Reactivity of Germ Line Allelic Variants of a Broadly Neutralizing HIV-1 Antibody to a gp41 Fusion Intermediate Conformation

Genetic factors, as well as antigenic stimuli, can influence antibody repertoire formation. Moreover, the affinity of antigen for unmutated naïve B cell receptors determines the threshold for activation of germinal center antibody responses. The gp41 2F5 broadly neutralizing antibody (bNAb) uses the...

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Main Authors: Alam, S. Munir, Liao, Hua-Xin, Dennison, S. Moses, Jaeger, Frederick, Parks, Robert, Anasti, Kara, Foulger, Andrew, Donathan, Michele, Lucas, Judith, Verkoczy, Laurent, Nicely, Nathan, Tomaras, Georgia D., Kelsoe, Garnett, Chen, Bing, Kepler, Thomas B., Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209283/
https://ncbi.nlm.nih.gov/pubmed/21917975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05680-11
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