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Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution

The conserved membrane-proximal external region (MPER) of HIV-1 envelope is a target for the rare broadly neutralizing 2F5, Z13, and 4E10 monoclonal antibodies (mAbs). One strategy to elicit such antibodies is to design an immunogen with increased exposure of the 2F5 and 4E10 mAb epitopes. In this s...

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Autori principali: Shen, Xiaoying, Dennison, S. Moses, Liu, Pinghuang, Gao, Feng, Jaeger, Frederick, Montefiori, David C., Verkoczy, Laurent, Haynes, Barton F., Alam, S. Munir, Tomaras, Georgia D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851912/
https://ncbi.nlm.nih.gov/pubmed/20231447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912381107
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