Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions

The binding of neutralizing antibodies 2F5 and 4E10 to human immunodeficiency virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 membrane proximal external region (MPER) epitopes. In this study, we have used several biophysical tools to examine the secondary structure, orientation,...

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Main Authors: Dennison, S. Moses, Stewart, Shelley M., Stempel, Kathryn C., Liao, Hua-Xin, Haynes, Barton F., Alam, S. Munir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748034/
https://ncbi.nlm.nih.gov/pubmed/19640992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00571-09
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