Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions

The binding of neutralizing antibodies 2F5 and 4E10 to human immunodeficiency virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 membrane proximal external region (MPER) epitopes. In this study, we have used several biophysical tools to examine the secondary structure, orientation,...

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Bibliographic Details
Main Authors: Dennison, S. Moses, Stewart, Shelley M., Stempel, Kathryn C., Liao, Hua-Xin, Haynes, Barton F., Alam, S. Munir
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748034/
https://ncbi.nlm.nih.gov/pubmed/19640992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00571-09
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