Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane

Failure to elicit broadly neutralizing (bNt) antibodies (Abs) against the membrane-proximal external region of HIV-1 gp41 (MPER) reflects the difficulty of mimicking its neutralization-competent structure (NCS). Here, we analyzed MPER antigenicity in the context of the plasma membrane and identified...

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Bibliographische Detailangaben
Hauptverfasser: Montero, Marinieve, Gulzar, Naveed, Klaric, Kristina-Ana, Donald, Jason E., Lepik, Christa, Wu, Sampson, Tsai, Sue, Julien, Jean-Philippe, Hessell, Ann J., Wang, Shixia, Lu, Shan, Burton, Dennis R., Pai, Emil F., DeGrado, William F., Scott, Jamie K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302331/
https://ncbi.nlm.nih.gov/pubmed/22238313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06349-11
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