Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development. Using cryo-electron microscopy, we describe the co...

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Détails bibliographiques
Auteurs principaux: Tran, Erin E. H., Borgnia, Mario J., Kuybeda, Oleg, Schauder, David M., Bartesaghi, Alberto, Frank, Gabriel A., Sapiro, Guillermo, Milne, Jacqueline L. S., Subramaniam, Sriram
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395603/
https://ncbi.nlm.nih.gov/pubmed/22807678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002797
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