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Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development. Using cryo-electron microscopy, we describe the co...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395603/ https://ncbi.nlm.nih.gov/pubmed/22807678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002797 |
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