Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

Germline precursors and intermediates of broadly neutralizing antibodies (bNAbs) are essential to the understanding of humoral response to HIV-1 infection and B-cell lineage vaccine design. Using a native-like gp140 trimer probe, we examined antibody libraries constructed from donor-17, the source o...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: He, Linling, Lin, Xiaohe, de Val, Natalia, Saye-Francisco, Karen L., Mann, Colin J., Augst, Ryan, Morris, Charles D., Azadnia, Parisa, Zhou, Bin, Sok, Devin, Ozorowski, Gabriel, Ward, Andrew B., Burton, Dennis R., Zhu, Jiang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573810/
https://ncbi.nlm.nih.gov/pubmed/28883821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01025
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