Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens

Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycoprotein (Env) trimer include conformational and structural instability. Stabilized soluble trimers such as BG505 SOSIP.664 mimic the structure of virion-associated Env but nevertheless sample different conformational st...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Schiffner, Torben, de Val, Natalia, Russell, Rebecca A., de Taeye, Steven W., de la Peña, Alba Torrents, Ozorowski, Gabriel, Kim, Helen J., Nieusma, Travis, Brod, Florian, Cupo, Albert, Sanders, Rogier W., Moore, John P., Ward, Andrew B., Sattentau, Quentin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702668/
https://ncbi.nlm.nih.gov/pubmed/26512083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01942-15
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