Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. W...

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發表在:PLoS Pathog
Main Authors: Torrents de la Peña, Alba, Rantalainen, Kimmo, Cottrell, Christopher A., Allen, Joel D., van Gils, Marit J., Torres, Jonathan L., Crispin, Max, Sanders, Rogier W., Ward, Andrew B.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658011/
https://ncbi.nlm.nih.gov/pubmed/31306470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007920
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