Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes

Soluble, recombinant native-like envelope glycoprotein (Env) trimers of various human immunodeficiency virus type 1 (HIV-1) genotypes are being developed for structural studies and as vaccine candidates aimed at the induction of broadly neutralizing antibodies (bNAbs). The prototypic design is desig...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ringe, Rajesh P., Ozorowski, Gabriel, Yasmeen, Anila, Cupo, Albert, Cruz Portillo, Victor M., Pugach, Pavel, Golabek, Michael, Rantalainen, Kimmo, Holden, Lauren G., Cottrell, Christopher A., Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., Klasse, P. J., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446630/
https://ncbi.nlm.nih.gov/pubmed/28381572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00264-17
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