High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

Soluble envelope glycoprotein (Env) trimers (SOSIP.664 gp140) are attractive HIV-1 vaccine candidates, with structures that mimic the native membrane-bound Env spike (gp160). Since engineering trimers can be limited by the difficulty of rationally predicting beneficial mutations, here we used a more...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sullivan, Jonathan T., Sulli, Chidananda, Nilo, Alberto, Yasmeen, Anila, Ozorowski, Gabriel, Sanders, Rogier W., Ward, Andrew B., Klasse, P. J., Moore, John P., Doranz, Benjamin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660478/
https://ncbi.nlm.nih.gov/pubmed/28878072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00862-17
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