Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases

av Diez, Lisa, Wegmann, Susanne
I publikationen Front Neurol (2020)

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

av Wegmann, Susanne, Medalsy, Izhar D., Mandelkow, Eckhard, Müller, Daniel J.
Publicerad 2013

Formation, release, and internalization of stable tau oligomers in cells

av Wegmann, Susanne, Nicholls, Samantha, Takeda, Shuko, Fan, Zhanyun, Hyman, Bradley T.
I publikationen J Neurochem (2016)

Competing Interactions Stabilize Pro- and Anti-aggregant Conformations of Human Tau

av Wegmann, Susanne, Schöler, Jonas, Bippes, Christian A., Mandelkow, Eckhard, Muller, Daniel J.
Publicerad 2011

Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

av Wegmann, Susanne, Jung, Yu Jin, Chinnathambi, Subashchandrabose, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Muller, Daniel J.
Publicerad 2010

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

av Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Publicerad 2013

Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes

av Mari, Stefania A., Wegmann, Susanne, Tepper, Katharina, Hyman, Bradley T., Mandelkow, Eva-Maria, Mandelkow, Eckhard, Müller, Daniel J.
I publikationen Nano Lett (2018)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

av Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Publicerad 2014

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

av Hernández-Vega, Amayra, Braun, Marcus, Scharrel, Lara, Jahnel, Marcus, Wegmann, Susanne, Hyman, Bradley T., Alberti, Simon, Diez, Stefan, Hyman, Anthony A.
I publikationen Cell Rep (2017)

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

av Rudinskiy, Nikita, Hawkes, Jonathan M, Wegmann, Susanne, Kuchibhotla, Kishore V, Muzikansky, Alona, Betensky, Rebecca A, Spires-Jones, Tara L, Hyman, Bradley T
I publikationen Acta Neuropathol Commun (2014)

A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type

av Kara, Eleanna, Marks, Jordan D., Roe, Allyson D., Commins, Caitlin, Fan, Zhanyun, Calvo-Rodriguez, Maria, Wegmann, Susanne, Hudry, Eloise, Hyman, Bradley T.
I publikationen J Biol Chem (2018)

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

av Kopeikina, Katherine J., Wegmann, Susanne, Pitstick, Rose, Carlson, George A., Bacskai, Brian J., Betensky, Rebecca A., Hyman, Bradley T., Spires-Jones, Tara L.
Publicerad 2013

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells

av Tepper, Katharina, Biernat, Jacek, Kumar, Satish, Wegmann, Susanne, Timm, Thomas, Hübschmann, Sabrina, Redecke, Lars, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
I publikationen J Biol Chem (2014)

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease

av Hori, Yukiko, Takeda, Shuko, Cho, Hansang, Wegmann, Susanne, Shoup, Timothy M., Takahashi, Kazue, Irimia, Daniel, Elmaleh, David R., Hyman, Bradley T., Hudry, Eloise
I publikationen J Biol Chem (2015)

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

av Pickett, Eleanor K., Henstridge, Christopher M., Allison, Elizabeth, Pitstick, Rose, Pooler, Amy, Wegmann, Susanne, Carlson, George, Hyman, Bradley T., Spires‐Jones, Tara L.
I publikationen Synapse (2017)

Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

av Kastanenka, Ksenia V., Hou, Steven S., Shakerdge, Naomi, Logan, Robert, Feng, Danielle, Wegmann, Susanne, Chopra, Vanita, Hawkes, Jonathan M., Chen, Xiqun, Bacskai, Brian J.
I publikationen PLoS One (2017)

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

av Busche, Marc Aurel, Wegmann, Susanne, Dujardin, Simon, Commins, Caitlin, Schiantarelli, Julia, Klickstein, Naomi, Kamath, Tarun V., Carlson, George A., Nelken, Israel, Hyman, Bradley T.
I publikationen Nat Neurosci (2018)

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

av Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.
Publicerad 2014

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Age...

av Fu, Hongjun, Hussaini, S. Abid, Wegmann, Susanne, Profaci, Caterina, Daniels, Jacob D., Herman, Mathieu, Emrani, Sheina, Figueroa, Helen Y., Hyman, Bradley T., Davies, Peter, Duff, Karen E.
I publikationen PLoS One (2016)

LRP1 is a master regulator of tau uptake and spread

av Rauch, Jennifer N., Luna, Gabriel, Guzman, Elmer, Audouard, Morgane, Challis, Collin, Sibih, Youssef E., Leshuk, Carolina, Hernandez, Israel, Wegmann, Susanne, Hyman, Bradley T., Gradinaru, Viviana, Kampmann, Martin, Kosik, Kenneth S.
I publikationen Nature (2020)