Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics

by Wang, Shutao, Kugelman, Tara, Buch, Amanda, Herman, Mathieu, Han, Yang, Karakatsani, Maria Eleni, Hussaini, S. Abid, Duff, Karen, Konofagou, Elisa E.
Published in Sci Rep (2017)

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3β Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precur...

by Wen, Yi, Planel, Emmanuel, Herman, Mathieu, Figueroa, Helen Y., Wang, Lili, Liu, Li, Lau, Lit-Fui, Yu, Wai Haung, Duff, Karen E.
Published in J Neurosci (2008)

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease

by Fu, Hongjun, Rodriguez, Gustavo A., Herman, Mathieu, Emrani, Sheina, Nahmani, Eden, Barrett, Geoffrey, Figueroa, Helen Y., Goldberg, Eliana, Hussaini, S. Abid, Duff, Karen E.
Published in Neuron (2017)

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Age...

by Fu, Hongjun, Hussaini, S. Abid, Wegmann, Susanne, Profaci, Caterina, Daniels, Jacob D., Herman, Mathieu, Emrani, Sheina, Figueroa, Helen Y., Hyman, Bradley T., Davies, Peter, Duff, Karen E.
Published in PLoS One (2016)

Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms

by Planel, Emmanuel, Tatebayashi, Yoshitaka, Miyasaka, Tomohiro, Liu, Li, Wang, Lili, Herman, Mathieu, Yu, W. Haung, Luchsinger, Jose A., Wadzinski, Brian, Duff, Karen E., Takashima, Akihiko
Published in J Neurosci (2007)

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

by Congdon, Erin E., Wu, Jessica W., Myeku, Natura, Figueroa, Yvette H., Herman, Mathieu, Marinec, Paul S., Gestwicki, Jason E., Dickey, Chad A., Yu, W. Haung, Duff, Karen E.
Published 2012

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Aβ accumulation

by Muhammad, Alim, Flores, Ingrid, Zhang, Hong, Yu, Rui, Staniszewski, Agnieszka, Planel, Emmanuel, Herman, Mathieu, Ho, Lingling, Kreber, Robert, Honig, Lawrence S., Ganetzky, Barry, Duff, Karen, Arancio, Ottavio, Small, Scott A.
Published 2008

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

by Wu, Jessica W., Herman, Mathieu, Liu, Li, Simoes, Sabrina, Acker, Christopher M., Figueroa, Helen, Steinberg, Joshua I., Margittai, Martin, Kayed, Rakez, Zurzolo, Chiara, Di Paolo, Gilbert, Duff, Karen E.
Published 2013

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

by Planel, Emmanuel, Krishnamurthy, Pavan, Miyasaka, Tomohiro, Liu, Li, Herman, Mathieu, Kumar, Asok, Bretteville, Alexis, Figueroa, Helen Y., Haung Yu, Wai, Whittington, Robert A., Davies, Peter, Takashima, Akihiko, Nixon, Ralph A., Duff, Karen E.
Published 2008

Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia

by Planel, Emmanuel, Richter, Karl E. G., Nolan, Charles E., Finley, James E., Liu, Li, Wen, Yi, Krishnamurthy, Pavan, Herman, Mathieu, Wang, Lili, Schachter, Joel B., Nelson, Robert B., Lau, Lit-Fui, Duff, Karen E.
Published in J Neurosci (2007)

Transcriptional regulation of β-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

by Wen, Yi, Yu, W. Haung, Maloney, Bryan, Bailey, Jason, Ma, Junrong, Marié, Isabelle, Maurin, Thomas, Wang, Lili, Figueroa, Helen, Herman, Mathieu, Krishnamurthy, Pavan, Liu, Li, Planel, Emmanuel, Lau, Lit-Fui, Lahiri, Debomoy K., Duff, Karen
Published 2008

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

by Miranda, Andre M., Herman, Mathieu, Cheng, Rong, Nahmani, Eden, Barrett, Geoffrey, Micevska, Elizabeta, Fontaine, Gaelle, Potier, Marie-Claude, Head, Elizabeth, Schmitt, Frederick A., Lott, Ira T., Jiménez-Velázquez, Ivonne Z., Antonarakis, Stylianos E., Paolo, Gilbert Di, Lee, Joseph H., Hussaini, S. Abid, Marquer, Catherine
Published in Cell Rep (2018)

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

by Nuriel, Tal, Angulo, Sergio L., Khan, Usman, Ashok, Archana, Chen, Qiuying, Figueroa, Helen Y., Emrani, Sheina, Liu, Li, Herman, Mathieu, Barrett, Geoffrey, Savage, Valerie, Buitrago, Luna, Cepeda-Prado, Efrain, Fung, Christine, Goldberg, Eliana, Gross, Steven S., Hussaini, S. Abid, Moreno, Herman, Small, Scott A., Duff, Karen E.
Published in Nat Commun (2017)

Neuronal activity enhances tau propagation and tau pathology in vivo

by Wu, Jessica W., Hussaini, Syed A., Bastille, Isle M., Rodriguez, Gustavo A., Mrejeru, Ana, Rilett, Kelly, Sanders, David W., Cook, Casey, Fu, Hongjun, Boonen, Rick A.C.M., Herman, Mathieu, Nahmani, Eden, Emrani, Sheina, Helen Figueroa, Y., Diamond, Marc I., Clelland, Catherine L., Wray, Selina, Duff, Karen E.
Published in Nat Neurosci (2016)