Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

In Alzheimer's disease, tau is hyperphosphorylated, which is thought to detach it from microtubules (MTs), induce MT destabilization, and promote aggregation. Using a previously described in vivo model, we investigated whether hyperphosphorylation impacts tau function in wild-type and transgeni...

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Detalhes bibliográficos
Main Authors: Planel, Emmanuel, Krishnamurthy, Pavan, Miyasaka, Tomohiro, Liu, Li, Herman, Mathieu, Kumar, Asok, Bretteville, Alexis, Figueroa, Helen Y., Haung Yu, Wai, Whittington, Robert A., Davies, Peter, Takashima, Akihiko, Nixon, Ralph A., Duff, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610528/
https://ncbi.nlm.nih.gov/pubmed/19036972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4101-08.2008
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