Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

Alzheimer's disease (AD) brains contain neurofibrillary tangles (NFTs) composed of abnormally hyperphosphorylated tau protein. Regional reductions in cerebral glucose metabolism correlating to NFT densities have been reported in AD brains. Assuming that reduced glucose metabolism might cause ab...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Planel, Emmanuel, Miyasaka, Tomohiro, Launey, Thomas, Chui, De-Hua, Tanemura, Kentaro, Sato, Shinji, Murayama, Ohoshi, Ishiguro, Koichi, Tatebayashi, Yoshitaka, Takashima, Akihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Cellular/Molecular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729502/
https://ncbi.nlm.nih.gov/pubmed/15014115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5561-03.2004
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi