Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

Tau hyperphosphorylation is one hallmark of Alzheimer's disease (AD) pathology. Pharmaceutical companies have thus developed kinase inhibitors aiming to reduce tau hyperphosphorylation. One obstacle in screening for tau kinase inhibitors is the low phosphorylation levels of AD-related phospho-e...

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Detalhes bibliográficos
Main Authors: Bretteville, Alexis, Marcouiller, François, Julien, Carl, El Khoury, Noura B., Petry, Franck R., Poitras, Isabelle, Mouginot, Didier, Lévesque, Georges, Hébert, Sébastien S., Planel, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386519/
https://ncbi.nlm.nih.gov/pubmed/22761989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00480
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