Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

Tau hyperphosphorylation is one hallmark of Alzheimer's disease (AD) pathology. Pharmaceutical companies have thus developed kinase inhibitors aiming to reduce tau hyperphosphorylation. One obstacle in screening for tau kinase inhibitors is the low phosphorylation levels of AD-related phospho-e...

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Главные авторы: Bretteville, Alexis, Marcouiller, François, Julien, Carl, El Khoury, Noura B., Petry, Franck R., Poitras, Isabelle, Mouginot, Didier, Lévesque, Georges, Hébert, Sébastien S., Planel, Emmanuel
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386519/
https://ncbi.nlm.nih.gov/pubmed/22761989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00480
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