3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer’s disease (AD). Tau pathology was compared at four timepoints, up to 34 months as it sprea...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Fu, Hongjun, Hussaini, S. Abid, Wegmann, Susanne, Profaci, Caterina, Daniels, Jacob D., Herman, Mathieu, Emrani, Sheina, Figueroa, Helen Y., Hyman, Bradley T., Davies, Peter, Duff, Karen E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965059/
https://ncbi.nlm.nih.gov/pubmed/27466814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159463
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