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Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease

The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spat...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Fu, Hongjun, Rodriguez, Gustavo A., Herman, Mathieu, Emrani, Sheina, Nahmani, Eden, Barrett, Geoffrey, Figueroa, Helen Y., Goldberg, Eliana, Hussaini, S. Abid, Duff, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363269/
https://ncbi.nlm.nih.gov/pubmed/28111080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.12.023
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