A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Excitatory neurons are preferentially impaired in early Alzheimer’s disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to inhibitory neurons, not only...

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Publicat a:Nat Neurosci
Autors principals: Fu, Hongjun, Possenti, Andrea, Freer, Rosie, Nakano, Yoshikazu, Hernandez Villegas, Nancy C., Tang, Maoping, Cauhy, Paula V. M, Lassus, Benjamin A., Chen, Shuo, Fowler, Stephanie L., Figueroa, Helen Y., Huey, Edward D., Johnson, Gail V.W., Vendruscolo, Michele, Duff, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330709/
https://ncbi.nlm.nih.gov/pubmed/30559469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0298-7
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